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17
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Hematology & Oncology Lessons
Canada pathway · 17 lessons
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Hematology & Oncology lessons — NCLEX-RN (NCLEX-RN) | NurseNest
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Lab values & correlations
Medication math
Skills refreshers
Pharmacology practice
Master telemetry through interactive ECG simulation
Prioritization & delegation
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Hematology & Oncology Lessons
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17 lessons
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Acute Chest Syndrome in Sickle Cell Disease
Acute chest syndrome (ACS) is the leading cause of death and the second most common reason for hospitalization in patients with sickle cell disease (SCD).
Start
Acute Hemolytic Transfusion Reaction For
An acute hemolytic transfusion reaction (AHTR) is the most serious and potentially fatal complication of blood transfusion, occurring when pre-formed recipient antibodies (most commonly anti-A or anti-B isohemagglutinins) attack and rapidly destroy transfused donor red blood cells.
Start
Acute Lymphoblastic Leukemia
Acute lymphoblastic leukemia (ALL) results from malignant transformation of lymphoid progenitor cells in the bone marrow, producing clonal proliferation of immature lymphoblasts that crowd out normal hematopoietic cells, causing bone marrow failure.
Start
Acute Promyelocytic Leukemia (APL)
Acute promyelocytic leukemia (APL) is a distinct subtype of acute myeloid leukemia (AML-M3 in the FAB classification) characterized by the accumulation of abnormal promyelocytes in the bone marrow and a uniquely dangerous coagulopathy.
Start
ALL and AML
Acute leukemias are clonal malignancies of hematopoietic progenitor cells characterized by uncontrolled proliferation of immature blast cells (>20% blasts in bone marrow) that crowd out normal hematopoiesis.
Start
Blood Transfusion: Administration
Blood transfusion reactions result from recipient immune response to foreign antigens on donor blood components.
Start
Chronic Lymphocytic Leukemia
Chronic lymphocytic leukemia (CLL) is the most common adult leukemia in Western countries, characterized by the clonal proliferation and progressive accumulation of functionally incompetent, mature-appearing CD5-positive B lymphocytes in the peripheral blood, bone marrow, lymph nodes, and spleen.
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Hairy Cell Leukemia
Hairy cell leukemia (HCL) is a rare, indolent B-cell lymphoproliferative disorder characterized by accumulation of mature B lymphocytes with distinctive cytoplasmic projections ('hairy' appearance) in the bone marrow, spleen, and peripheral blood.
Start
Hematologic Disorders
Hematopoiesis occurs primarily in the bone marrow, where pluripotent hematopoietic stem cells differentiate into all blood cell lineages through growth factor-mediated signaling — erythropoietin (EPO) from the kidneys drives red blood cell production, thrombopoietin (TPO) regulates platelet…
Start
Iron Deficiency Anemia
Iron deficiency anemia (IDA) develops through three progressive stages: (1) iron depletion—reduced ferritin stores with normal hemoglobin; (2) iron-deficient erythropoiesis—low serum iron, elevated TIBC, reduced transferrin saturation (<20%), with early microcytosis; (3) iron deficiency anemia—low…
Start
Neutropenic Precautions and Febrile Neutropenia
Neutropenia is defined as an absolute neutrophil count (ANC) below 1500/mm3, with severe neutropenia below 500/mm3 and profound neutropenia below 100/mm3.
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Oncology
Advanced oncology nursing requires understanding cancer at the cellular and molecular level, including the mechanisms of tumor growth, metastasis, and treatment resistance.
Start
Primary CNS Lymphoma
Primary CNS lymphoma (PCNSL) is a rare, aggressive non-Hodgkin lymphoma arising within the brain, spinal cord, leptomeninges, or eyes without systemic lymphoma involvement.
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Sickle Cell Disease
Sickle cell disease (SCD) is an autosomal recessive hemoglobinopathy caused by a single nucleotide substitution (GAG→GTG) in the beta-globin gene on chromosome 11, resulting in hemoglobin S (HbS) where valine replaces glutamic acid at position 6.
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Sickle Cell Vaso-Occlusive Crisis
In sickle cell disease, the valine-for-glutamic acid substitution at position 6 of the beta-globin chain produces hemoglobin S.
Start
Transfusion-Related Acute Lung Injury (TRALI)
TRALI is a non-cardiogenic pulmonary edema occurring within 6 hours of transfusion.
Start
Warm Autoimmune Hemolytic Anemia
Warm autoimmune hemolytic anemia (AIHA) is caused by IgG autoantibodies that bind red blood cells (RBCs) optimally at body temperature (37 degrees C), opsonizing them for destruction by splenic macrophages via Fc-receptor-mediated phagocytosis (extravascular hemolysis).
Start
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