Systemic opioid analgesia remains an important component of labor pain management, particularly when neuraxial techniques such as epidural or spinal anesthesia are unavailable, contraindicated, or declined by the patient. Morphine, fentanyl, and meperidine are the agents most commonly encountered, and naloxone is the reversal agent every labor nurse must understand. Because all opioids readily cross the placenta and enter the fetal circulation, the timing of administration relative to anticipated delivery is critical to prevent neonatal respiratory depression at birth. The central nursing goal is to provide adequate maternal analgesia while minimizing fetal drug exposure. Achieving this requires understanding the pharmacokinetic differences among the agents, especially their onset, peak, and duration of action. Fentanyl, for example, has a very rapid onset and short duration, so a well-timed single dose exposes the fetus only briefly, whereas morphine and meperidine act longer and carry a wider neonatal risk window. Meperidine is especially concerning because its active metabolite, normeperidine, is neuroexcitatory, accumulates with repeated dosing, has a long half-life, and is not reversed by naloxone. For this reason, the nurse times opioid administration so...