Pharmacotherapeutics: Core Principles, OTC encompasses prescriptive authority principles, pharmacokinetic/pharmacodynamic considerations, and safety monitoring specific to pharmacotherapeutics. Connect Pharmacotherapeutics: Core Principles, OTC to bedside cues you will reassess first: vitals trends, work of breathing, perfusion, mentation, and pain or ischemic equivalents when relevant. NCLEX items often reward recognizing when subtle instability outweighs reassurance, then selecting nursing actions that protect airway, circulation, and neurologic status before routine tasks.