Negative Pressure Wound Therapy involves specific pathophysiological mechanisms requiring systematic evaluation by the nurse practitioner. Negative Pressure Wound Therapy pathophysiology includes disruption of normal cellular function, tissue homeostasis, and organ-specific processes that drive the clinical presentation and guide evidence-based management decisions. Connect Negative Pressure Wound Therapy to bedside cues you will reassess first: vitals trends, work of breathing, perfusion, mentation, and pain or ischemic equivalents when relevant. NCLEX items often reward recognizing when subtle instability outweighs reassurance, then selecting nursing actions that protect airway, circulation, and neurologic status before routine tasks.