Overview
Clinical Meaning
Atrial Fibrillation involves disorganized electrical activity from multiple re entrant wavelets and ectopic foci from pulmonary vein ostia.
WHNP
WHNP
Atrial Fibrillation involves disorganized electrical activity from multiple re-entrant wavelets and ectopic foci from pulmonary vein ostia. Atrial myocytes undergo electrical remodeling with shortened action potential duration. Structural remodeling includes atrial fibrosis creating substrate for re-entry. Loss of atrial kick reduces cardiac output by 15-25% and causes left atrial appendage stasis increasing thromboembolic risk. CHA2DS2-VASc score guides anticoagulation.
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