Overview
Clinical Meaning
Atrial Fibrillation involves disorganized electrical activity from multiple re entrant wavelets and ectopic foci from pulmonary vein ostia.
PNP-PC
PNP-PC
Atrial Fibrillation involves disorganized electrical activity from multiple re-entrant wavelets and ectopic foci from pulmonary vein ostia. Atrial myocytes undergo electrical remodeling with shortened action potential duration. Structural remodeling includes atrial fibrosis creating substrate for re-entry. Loss of atrial kick reduces cardiac output by 15-25% and causes left atrial appendage stasis increasing thromboembolic risk. CHA2DS2-VASc score guides anticoagulation.
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