Overview
Clinical Meaning
Heart Failure with Preserved Ejection Fraction (HFpEF, EF =50%) represents ~50% of HF cases driven by diastolic dysfunction from myocardial stiffness and impaired relaxation.
FNP
FNP
Heart Failure with Preserved Ejection Fraction (HFpEF, EF >=50%) represents ~50% of HF cases driven by diastolic dysfunction from myocardial stiffness and impaired relaxation. Microvascular endothelial inflammation reduces nitric oxide bioavailability, decreasing cGMP and PKG activity. This leads to unphosphorylated titin increasing passive myocardial stiffness. Concurrent cardiomyocyte hypertrophy and interstitial fibrosis further impair diastolic filling. The H2FPEF score helps diagnose HFpEF.
Unlock full lesson + practice questions
4 more sections with scenarios, priorities, and review drills.
Next study step
Finish the lesson first, then choose a focused activity to apply what you just reviewed.
Continue studying
Sign in to save progress on this lesson.
Unlock the interactive lesson quiz with a plan that includes this FNP pathway. You can still explore topic-filtered questions from the bank hubs below.