Overview
Introduction
Constitutional (insidious, often months): - Profound fatigue and weakness — the most common presenting complaint - Weight loss and anorexia - Salt craving — a distinctive clue driven by aldosterone deficiency Gastrointestinal: nausea, vomiting, diffuse abdominal pain, and diarrhea. GI symptoms are common and often lead to misdiagnosis; worsening vomiting in a known Addison patient is an escalation trigger, not a stomach bug. Cardiovascular: hypotension, especially postural — dizziness and syncope on standing. Tachycardia. Skin — primary disease only: hyperpigmentation of sun-exposed areas, palmar creases, knuckles, scars, and buccal mucosa. Vitiligo may coexist where the cause is autoimmune. Neuropsychiatric: depression, irritability, poor concentration, and confusion when severe. Hypoglycemia symptoms — shakiness, sweating, confusion — particularly in children and during fasting or illness. Clinical trajectory check Link new findings to the underlying process and the compensatory response that is succeeding or failing. Reassess objective trends such as perfusion, oxygenation, mental status, pain pattern, labs, and response to time-limited interventions so the next action reflects improvement or deterioration rather than a memorized label. For NCLEX-RN (Canada), items rarely announce the topic in...
